Not sure if this will help in your particular case....but
When we first started buttons we tried setting up 3 blanks at a time(4X24") with mixed results.
Eventually wound up going with one jigging that made blanks a 30-60 second swap out, zeroing to the spoilboard right next to the same bolt every time(made it home position in the file), and simply changed the bit and zeroed, then ran the same toolpath with all six blanks, then swapped bits and repeated the new toolpath for up to 4 tools.
Replay Recent command/enter/enter, and from cutting to cutting again was almost never more than a minute:)
Even .08" buttonhole countersinks were accurately placed if done the same day.
Made 180-360 buttons a day....and then did the same with keyfobs.
Toolpaths varied from 20:00 to 4:00, but swapping out blanks was easy.
Spoilboard and blanks had to be flat, Flat,FLAT and as close to identical as possible
Hope this is pertinent and helpful.